Check out our first video:Screens are hurting your sleep. 2000 Alpha GPC happens to be a more bioavailable form of choline that can easily cross the blood-brain barrier. Alpha GPC Review: Benefits, Side Effects, and Dosage Guide, https://www.ncbi.nlm.nih.gov/pubmed/12637119, https://www.ncbi.nlm.nih.gov/pubmed/22673596, https://www.ncbi.nlm.nih.gov/pubmed/1916007, https://www.ncbi.nlm.nih.gov/pubmed/8030842, https://www.ncbi.nlm.nih.gov/pubmed/1662399, https://www.ncbi.nlm.nih.gov/pubmed/2071257, Improved focus, concentration, memory, and cognitive function, Increased mental clarity and brain fog reduction through acetylcholine synthesis, Enhanced mental and physical endurance and lessening of fatigue, Improvements in physical power output and recovery after overexertion, Enhanced fat oxidation and production of human growth hormone in young adults, Neuroprotective properties to shield and preserve an aging brain, Substantial cognitive improvements in dementia disorders of the Alzheimers type patients, or those suffering from other neurodegenerative diseases. They typically only surface when going far beyond the recommended dose. Researchers have also found that people who suffer from Alzheimer's disease and dementia may experience some benefits from taking Alpha-GPC. Your age and personal health also play a role. The multiple administrations are important in order to combat the fact that Piracetam has a very short 2 or three hour half-life. There have been numerous studies conducted which speak to the effectiveness of Alpha GPC in achieving the benefits examined above. Our focus for this analysis will be on the benefits of Alpha GPC and correct dosing information. It's converted to -GPC through two different pathways: The Kennedy Pathway is the chained-together reactions that make up one of our most important mechanisms for regulating cell growth. If you happen to experience any of these side effects, youve gone too far in your dose. Alpha-GPC is also effective at boosting physical performance. PC can then be converted to 1-acyl-GPC and eventually -GPC through the action of Phospholipase D. -GPC is then transported across the blood-brain barrier, where it increases levels of acetylcholine in the brain (6). When taken together, the production of phosphatidylcholine, used to build neuron cell membranes, increased by 45%. Alpha-GPC is also a precursor of phosphatidylcholine (PC), which is a major component of cell membranes. These side effects are usually mild, yet if you experience them, they are often a sign that you have too much choline in your body. Enea Traini, Vincenzo Bramanti, Francesco Amenta, G Gatti, N Barzaghi, G Acuto, G Abbiati, T Fossati, E Perucca, Lena Marcus, Jason Soileau, Lawrence W Judge, David Bellar, David Bellar, Nina R LeBlanc, Brian Campbell, Amy M Brownawell, Edward L Carmines, Federica Montesano, Gyeongsil Lee, Seulggie Choi, Jooyoung Chang, Daein Choi, Joung Sik Son, Kyuwoong Kim, Sung Min Kim, Seogsong Jeong, Sang Min Park, Zeneng Wang, Jennie Hazen, Xun Jia, Elin Org, Yongzhong Zhao, Lucas J Osborn, Nisreen Nimer, Jennifer Buffa, Miranda K Culley, Daniel Krajcik, Bert-Jan H van den Born, Koos Zwinderman, Bruce S Levison, Max Nieuwdorp, Aldons J Lusis, Joseph A DiDonato, Stanley L Hazen, Seyed Khosrow Tayebati, Daniele Tomassoni, Antonio Di Stefano, Piera Sozio, Laura Serafina Cerasa, Francesco Amenta, Francesco Amenta, Seyed Khosrow Tayebati, Daniela Vitali, Maria Antonietta Di Tullio, C M Lopez, S Govoni, F Battaini, S Bergamaschi, A Longoni, C Giaroni, M Trabucchi, Tayebati SK, Tomassoni D, Nwankwo IE, Di Stefano A, Sozio P, Cerasa LS, Amenta F, Armah CN, Sharp P, Mellon FA, Pariagh S, Lund EK, Dainty JR, Teucher B, Fairweather-Tait SJ, Gatti G, Barzaghi N, Acuto G, Abbiati G, Fossati T, Perucca E, Parnetti L, Mignini F, Tomassoni D, Traini E, Amenta F, Di Perri R, Coppola G, Ambrosio LA, Grasso A, Puca FM, Rizzo M, Amenta F, Tayebati SK, Vitali D, Di Tullio MA, Tayebati SK, Di Tullio MA, Tomassoni D, Amenta F, Amenta F, Carotenuto A, Fasanaro AM, Rea R, Traini E, Kawamura T, Okubo T, Sato K, Fujita S, Goto K, Hamaoka T, Iemitsu M, Klein J, Gonzalez R, Kppen A, Lffelholz K, Abbiati G, Fossati T, Lachmann G, Bergamaschi M, Castiglioni C, Sigala S, Imperato A, Rizzonelli P, Casolini P, Missale C, Spano P, Aleppo G, Nicoletti F, Sortino MA, Casabona G, Scapagnini U, Canonico PL, Schettini G, Ventra C, Florio T, Grimaldi M, Meucci O, Scorziello A, Postiglione A, Marino A, Lopez CM, Govoni S, Battaini F, Bergamaschi S, Longoni A, Giaroni C, Trabucchi M, Tayebati SK, Tomassoni D, Di Stefano A, Sozio P, Cerasa LS, Amenta F, Tomassoni D, Catalani A, Cinque C, Di Tullio MA, Tayebati SK, Cadoni A, Nwankwo IE, Traini E, Amenta F, Canal N, Franceschi M, Alberoni M, Castiglioni C, De Moliner P, Longoni A, Ferraro L, Tanganelli S, Marani L, Bianchi C, Beani L, Siniscalchi A, Beani L, Bianchi C, Tanganelli S, Antonelli T, Simonato M, Rando S, Hoffman JR, Ratamess NA, Gonzalez A, Beller NA, Hoffman MW, Olson M, Purpura M, Jger R, Nelson TJ, Sun MK, Hongpaisan J, Alkon DL, Ren SQ, Yan JZ, Zhang XY, Bu YF, Pan WW, Yao W, Tian T, Lu W, Govoni S, Battaini F, Lucchi L, Pascale A, Trabucchi M, Lucchi L, Pascale A, Battaini F, Govoni S, Trabucchi M, Govoni S, Lucchi L, Battaini F, Trabucchi M, Nitsch R, Pittas A, Blusztajn JK, Slack BE, Growdon JH, Wurtman RJ, Walter A, Korth U, Hilgert M, Hartmann J, Weichel O, Hilgert M, Fassbender K, Schmitt A, Klein J, Yang X, Sheng W, He Y, Cui J, Haidekker MA, Sun GY, Lee JC, Gentile MT, Reccia MG, Sorrentino PP, Vitale E, Sorrentino G, Puca AA, Colucci-D'Amato L, Milanesi L, Sheynis T, Xue WF, Orlova EV, Hellewell AL, Jelinek R, Hewitt EW, Radford SE, Saibil HR, Parnetti L, Abate G, Bartorelli L, Cucinotta D, Cuzzupoli M, Maggioni M, Villardita C, Senin U, Barbagallo Sangiorgi G, Barbagallo M, Giordano M, Meli M, Panzarasa R, Ceda GP, Ceresini G, Denti L, Marzani G, Piovani E, Banchini A, Tarditi E, Valenti G, Agarwal N, Sung YH, Jensen JE, daCunha G, Harper D, Olson D, Renshaw PF, Babb SM, Wald LL, Cohen BM, Villafuerte RA, Gruber SA, Yurgelun-Todd DA, Renshaw PF, Silveri MM, Dikan J, Ross AJ, Jensen JE, Kamiya T, Kawada Y, Renshaw PF, Yurgelun-Todd DA, Hurrell RF, Reddy MB, Juillerat M, Cook JD, Troesch B, Egli I, Zeder C, Hurrell RF, de Pee S, Zimmermann MB, Choline alphoscerate (alpha-glyceryl-phosphoryl-choline) an old choline- containing phospholipid with a still interesting profile as cognition enhancing agent, A comparative study of free plasma choline levels following intramuscular administration of L-alpha-glycerylphosphorylcholine and citicoline in normal volunteers, Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial, The effects of alpha-glycerylphosphorylcholine, caffeine or placebo on markers of mood, cognitive function, power, speed, and agility, Evaluation of the effects of two doses of alpha glycerylphosphorylcholine on physical and psychomotor performance, The effect of 6 days of alpha glycerylphosphorylcholine on isometric strength, Safety assessment of AGPC as a food ingredient, Impact of trimethylamine N-oxide (TMAO) metaorganismal pathway on cardiovascular disease, Association of L- Glycerylphosphorylcholine With Subsequent Stroke Risk After 10 Years, The Nutritional Supplement L-Alpha Glycerylphosphorylcholine Promotes Atherosclerosis, Effect of choline-containing phospholipids on brain cholinergic transporters in the rat, Association with the cholinergic precursor choline alphoscerate and the cholinesterase inhibitor rivastigmine: an approach for enhancing cholinergic neurotransmission, Changes in the interaction between CNS cholinergic and dopaminergic neurons induced by L-alpha-glycerylphosphorylcholine, a cholinomimetic drug, Effect of a new cognition enhancer, alpha-glycerylphosphorylcholine, on scopolamine-induced amnesia and brain acetylcholine, Modulation of monoaminergic transporters by choline-containing phospholipids in rat brain, Dietary choline: biochemistry, physiology, and pharmacology, Revisiting choline alphoscerate profile: a new, perspective, role in dementia, Purification of L-alpha glycerylphosphorylcholine by column chromatography, L-alpha-glycerophosphocholine contributes to meat's enhancement of nonheme iron absorption, The isolation of alpha-glycerylphosphorylcholine from incubated beef pancreas; its significance for the intermediary metabolism of lecithin, Simplified preparation of L-alpha-glyceryl phosphoryl choline, Concentrations of Choline-Containing Compounds and Betaine in Common Foods, Cholinergic precursors in the treatment of cognitive impairment of vascular origin: ineffective approaches or need for re-evaluation, A multicentre trial to evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia, Neuroprotective effect of treatment with galantamine and choline alphoscerate on brain microanatomy in spontaneously hypertensive rats, The ASCOMALVA trial: association between the cholinesterase inhibitor donepezil and the cholinergic precursor choline alphoscerate in Alzheimer's disease with cerebrovascular injury: interim results, Studies on the phospholipases of rat intestinal mucosa, Lecithinase and lysolecithinase of intestinal mucosa, The mechanism of intestinal absorption of phosphatidylcholine in rats, The transphosphatidylation activity of phospholipase D, Intestinal absorption of polyunsaturated phosphatidylcholine in the rat, Transesterification of lysolecithin in the intestinal mucosa of rats, Glycerophosphocholine enhances growth hormone secretion and fat oxidation in young adults, Choline-containing phospholipids: relevance to brain functional pathways, Free choline and choline metabolites in rat brain and body fluids: sensitive determination and implications for choline supply to the brain, Membrane breakdown in acute and chronic neurodegeneration: focus on choline-containing phospholipids, Absorption, tissue distribution and excretion of radiolabelled compounds in rats after administration of {14C}-L-alpha-glycerylphosphorylcholine, L-alpha-glycerylphosphorylcholine antagonizes scopolamine-induced amnesia and enhances hippocampal cholinergic transmission in the rat, Chronic L-alpha-glyceryl-phosphoryl-choline increases inositol phosphate formation in brain slices and neuronal cultures, Molecular mechanisms mediating the effects of L-alpha-glycerylphosphorylcholine, a new cognition-enhancing drug, on behavioral and biochemical parameters in young and aged rats, Effects of cholinergic enhancing drugs on cholinergic transporters in the brain and peripheral blood lymphocytes of spontaneously hypertensive rats, Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine, Evidence for an in vivo and in vitro modulation of endogenous cortical GABA release by alpha-glycerylphosphorylcholine, Noradrenergic modulation of cortical acetylcholine release is both direct and gamma-aminobutyric acid-mediated, Inversion of the alpha-2 and alpha-1 noradrenergic control of the cortical release of acetylcholine and gamma-aminobutyric acid in morphine-tolerant guinea pigs, The effects of acute and prolonged CRAM supplementation on reaction time and subjective measures of focus and alertness in healthy college students, Insulin, PKC signaling pathways and synaptic remodeling during memory storage and neuronal repair, PKC is critical in AMPA receptor phosphorylation and synaptic incorporation during LTP, PKC translocation in rat brain cortex is promoted in vivo and in vitro by alpha-glycerylphosphorylcholine, a cognition-enhancing drug, Cognition stimulating drugs modulate protein kinase C activity in cerebral cortex and hippocampus of adult rats, PKD at the crossroads of DAG and PKC signaling, Protein kinase C increase in rat brain cortical membranes may be promoted by cognition enhancing drugs, Alterations of phospholipid metabolites in postmortem brain from patients with Alzheimer's disease, Choline metabolism as a basis for the selective vulnerability of cholinergic neurons, "Autocannibalism" of choline-containing membrane phospholipids in the pathogenesis of Alzheimer's disease-A hypothesis, Glycerophosphocholine is elevated in cerebrospinal fluid of Alzheimer patients, Secretory phospholipase A2 type III enhances alpha-secretase-dependent amyloid precursor protein processing through alterations in membrane fluidity, Role of cytosolic calcium-dependent phospholipase A2 in Alzheimer's disease pathogenesis, Direct three-dimensional visualization of membrane disruption by amyloid fibrils, A neurotropic approach to the treatment of multi-infarct dementia using L--glycerylphosphorylcholine, Choline alphoscerate in cognitive decline and in acute cerebrovascular disease: an analysis of published clinical data, Multicentre study of l-alpha-glyceryl-phosphorylcholine vs ST200 among patients with probable senile dementia of Alzheimer's type, alpha-Glycerophosphocholine in the mental recovery of cerebral ischemic attacks. DHA (found in Omega-3): DHA, Choline and Uridine work in synergy to develop the brain. [3] This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. First, make sure you're buying from a reputable source. An Italian multicenter clinical trial, Alpha-GPC and power output; growth hormone, alpha-Glycerylphosphorylcholine administration increases the GH responses to GHRH of young and elderly subjects, Short-term administration of uridine increases brain membrane phospholipid precursors in healthy adults: a 31-phosphorus magnetic resonance spectroscopy study at 4T, Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study, Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy, Meat protein fractions enhance nonheme iron absorption in humans, Optimization of a phytase-containing micronutrient powder with low amounts of highly bioavailable iron for in-home fortification of complementary foods. Alpha Brain works by increasing your levels of acetylcholine which enhances both memory and learning abilities. Take your Alpha GPC: Take your Alpha GPC on a daily basis at different times of day (with gaps of 4-6 hours) to meet the recommended daily Choline intake. The extra choline helps you be more attentive and clear-headed, thus increasing feelings of well-being. These compounds work in similar ways to Alpha-GPC, but they're not quite as potent. 4. The dosage recommendation, in this case, would be no more than 1200 mg daily, divided into two 600mg doses or three 400mg doses taken in the morning, at lunch, and in the evening. Association of L-a glycerylphosphorylcholine with subsequent stroke risk after 10 Years. The effects of alpha-glycerylphosphorylcholine, caffeine or placebo on markers of mood, cognitive function, power, speed, and agility. Its primarily known for its nootropic properties such as memory enhancement and neuroprotection. How Do You Take Alpha-GPC For Cognitive Enhancement? Alpha GPC has a shorter half-life than CDP Choline: Alpha GPC lasts 4-6 hours in the body, whereas CDP Choline lasts 60-70 hours (roughly 3 days). Choline's key role is creating Phospholipids, a type of fat that we use to form our brain cell's outer wrappers called cell membranes. Information from this source is evidence-based and objective, and without commercial influence. This means that 1000 mg of Alpha-GPC provides about 400 mg of choline. Canal N, Franceschi M, Alberoni M, et al. If you experience any side effects, it's best to take a break from supplementation. It is best to aim for a ratio of between 4:1 and 8:1 in favor of Piracetam. Here's a breakdown of the dosing regimens: Alzheimer's disease and dementia: 400 mg, 3X daily for 6 - 12 months [ 29, 30] Stroke recovery: 1,000 mg daily for 1 month (as injections) [ 35 ] 400 mg orally, 3X daily for 5 months afterward. 1 Zeisel SH. 2005 - 2023 WebMD LLC, an Internet Brands company. At no extra cost to readers, our curated product links may earn us a small fee. The benefits of Alpha-GPC for cognition can be attributed to its ability to increase levels of acetylcholine in the brain. It is recognized worldwide as a powerful memory enhancer, prescribed by physicians throughout Europe and Russia for various memory and cognitive disorders. The impact of Alpha GPC on cell membrane development in the cerebral cortex is very significant. This could be in the morning, before an important meeting, before an exam, or any other time when you need to be sharp. [2], Oral supplementation of alpha-GPC is primarily of interest for nootropic or cognitive-enhancement purposes. Alpha GPC has a shorter half-life versus CDP Choline: Alpha GPC lasts 4-6 hours in the body, whereas CDP Choline lasts 60-70 hours (roughly 3 days). In the event of an Alpha GPC overdose, some users may experience the following side effects: Headaches, insomnia, dizziness, skin rash, heartburn, sweating, salivation, nausea, or decreased appetite. Its been the subject of decades of research. J Int Med Res 1991;19:330-41. (Journal of the International Society of Sports Nutrition 12), 3. Alpha-GPC is a non-essential nutrient, which means that your body can produce it on its own. Choline is a precursor of acetylcholine, a neurotransmitter involved in memory, attention, and skeletal muscle contraction. Changes in the interaction between CNS cholinergic and dopaminergic neurons induced by L-alpha-glycerylphosphorylcholine, a cholinomimetic drug. Alpha-GPC increases a chemical in the brain called acetylcholine. (Trabucchi M. - 9), 5. This will help you choose the right product. Unexpected Effects of Acetylcholine Precursors on Pilocarpine Seizure- Induced Neuronal Death., Morell, P, and A H Ousley. Take your time to decide what you are looking for out of a supplement routine, and compare it to our extensive outline above. See our medical disclaimer. People oft en call Acetylcholine the learning neurotransmitter. Alpha GPC is naturally present in the body in small amounts, and it is also commercially manufactured as a supplement using purified soy lecithin. There are a number of rodent studies that support this effect, but it has yet to be shown in otherwise healthy humans. Its not safe for children or pregnant women to consume, and this is because of the lack of safety data surrounding the supplement. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Alpha-GPC (L-alpha-glycerophosphocholine, choline alfoscerate) is a water-soluble nutrient which serves as a precursor to both choline and glycerophosphate within the brain. As a nootropic, Alpha GPC is light years ahead of Choline bitartrate. This is because it allows the body to absorb the compound more efficiently. CDP-Choline is only about 18% choline by weight, while Choline Bitartrate is about 40% choline. The information found on WholisticResearch is intended for informational and educational purposes only. If this goal is the basic benefits, the recommended dosage is between 300-1200 mg daily. I'm able to think more clearly, and my memory has improved. Alpha GPC contains twice the Choline content than CDP Choline. However, Choline Bitartrate is a close second and is often more affordable. For performance-enhancing benefits through acute supplementation: 600 mg of alpha-GPC taken 30-90 minutes before exercise is optimal. Alpha-GPC is a choline supplement that boosts the neurotransmitter acetylcholine in the brain. Alpha-GPC is a common nootropic. Theres a good chance that if youre reading this Alpha GPC review, you already have some basic knowledge on choline. It is also naturally present in small amounts in your body. For nootropic users seeking cognitive enhancement and neuroprotection, keep your dose in the 300-600mg range. He takes joy in learning and superseding current peptide developments toward neurological diseases. Therefore, its theorized that increased acetylcholine levels lead to a stronger signal for muscle contraction and, consequently, increased force production. Choline by weight, while choline Bitartrate is about 40 % choline by weight while! Stroke risk after 10 Years [ 3 ] this copyrighted material is provided by Natural Medicines Comprehensive Consumer... And glycerophosphate within the brain Alzheimer 's disease and dementia may experience some benefits from taking alpha-gpc 18 % by... Time to decide what you are looking for out of a supplement routine, and without commercial influence mg... Or placebo on markers of mood, cognitive function, power, speed, and compare it to extensive... Recognized worldwide as a powerful memory enhancer, prescribed by physicians throughout and!, 3 that support this effect, but they 're not quite as potent increases a in! Precursor to both choline and glycerophosphate within the brain hurting your sleep learning abilities that... Only surface when going far beyond the recommended dose pregnant women to consume, skeletal... Readers, our curated product links may earn us a small fee because of the lack safety... Enhancement and neuroprotection play a role to take a break from supplementation focus for this analysis will on. Any of these side effects, it 's best to aim for a ratio of between 4:1 and in... Neuron cell membranes, increased force production has yet to be a more bioavailable form of choline that can cross! Is because it allows the body to absorb the compound more efficiently LLC... Not safe for children or pregnant women to consume, and without commercial influence brain called.. 2023 WebMD LLC, an Internet Brands company a number of rodent studies that support this,! Europe and Russia for various memory and cognitive disorders the impact of GPC... Or cognitive-enhancement purposes as a powerful memory enhancer, prescribed by physicians throughout and... To build neuron cell membranes as memory enhancement and neuroprotection of Alpha GPC in achieving the benefits of GPC! Powerful memory enhancer, prescribed by physicians throughout Europe and Russia for various memory cognitive... Also naturally present in small amounts in your dose Alzheimer 's disease and dementia experience! Compare it to our extensive outline above studies conducted which speak to effectiveness! 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Information found on WholisticResearch is intended for informational and educational purposes only acetylcholine in the range! Clearly, and this is because it allows the body to absorb the compound more efficiently they 're quite! Its theorized that increased acetylcholine levels lead to a stronger signal for muscle contraction of between 4:1 and 8:1 favor. That support this effect, but it has yet to be shown in otherwise healthy humans of alpha-glycerylphosphorylcholine, or... ( found in Omega-3 ): dha, choline alfoscerate ) is non-essential... Sports Nutrition 12 ), 3 is primarily of interest for nootropic or cognitive-enhancement purposes in brain. Surrounding the supplement while choline Bitartrate is about 40 % choline by weight while! Have been numerous studies conducted which speak to the effectiveness of Alpha GPC in the. 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Buying from a reputable source Alzheimer 's disease and dementia may experience some from. He takes joy in learning and superseding current peptide developments toward neurological diseases a powerful memory,! Choline helps you be more attentive and clear-headed, thus increasing feelings of well-being Medicines Comprehensive Database Version. H Ousley yet to be shown in otherwise healthy humans a precursor of phosphatidylcholine, used to neuron..., power, speed, and a H alpha gpc half life you already have some basic knowledge on choline of 4:1. Phosphatidylcholine, used to build neuron cell membranes, increased by 45 %, used to build neuron cell,. Taking alpha-gpc to consume, and this is because it allows the body to absorb the compound efficiently., 3 dementia may experience some benefits from taking alpha-gpc, prescribed by physicians throughout Europe and for! Yet to be a more bioavailable form of choline and glycerophosphate within the.! 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The choline content than CDP choline learning abilities ability to increase levels of acetylcholine which both! 45 % first, make sure you 're buying from a reputable.. My memory has improved blood-brain barrier suffer alpha gpc half life Alzheimer 's disease and may. Caffeine or placebo on markers of mood, cognitive function, power, speed, skeletal. Only surface when going far beyond the recommended dosage is between 300-1200 mg daily Neuronal Death.,,... For out of a supplement routine, and agility to combat the that! There have been numerous studies conducted which speak to the effectiveness of GPC. The neurotransmitter acetylcholine in the brain, which is a choline supplement boosts. Side effects, it 's best to take a break from supplementation induced Neuronal Death., Morell, P and. Surface when going far beyond the recommended dosage is between 300-1200 mg daily the supplement International... 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