They can give you advice and prescribe creams to improve any symptoms you have. In the secondary analysis, overall survival was longer with EOX than with ECF, with a hazard ratio for death of 0.80 in the EOX group (95% CI, 0.66 to 0.97; P=0.02). I know I won't put gloves on to get things out of the fridge, so I pull my sleeves down over my hands. She still had a brilliant outcome from treatment . A low white blood cell count is sometimes called neutropenia. This treatment may cause a sore mouth and throat. There are some rare side effects that are not listed. Signs of a severe skin reaction include peeling or blistering of the skin. Kick it to the side and be positve. I'm one who had relatively mild effects from the Folfox/pump regime, limited to some nueropathy in hands and feet, cold sensitivity in my hands and throat, and fatigue, especially when it was real warm[SoCal area]. I have been using Eucerin cream on my hands and feet, and my calendar is cleared so that I can stay in bed if things get really bad. Back and can add some more Not sure if you read my profile. administration of oxaliplatin can be given. This includes your eyelashes, eyebrows, underarm, leg and sometimes pubic hair. That's a very annoying side effect. Mouth sores and ulcerscan be painful. This includes vitamins, herbal supplements and over the counter remedies. But some can be permanent. This treatment may affect your skin and nails. Sometimes people who have had the live shingles vaccine can get a shingles type rash. . Try to take gentle exercise, such as walking. Are you going to be on Avastin as well? You can help reduce the risk of developing a blood clot by: You may be given anticoagulants to help prevent a clot. Don't push yourself, rest when you start to feel tired and ask others for help. Talk to your doctor or nurse about effective contraception before starting treatment. They may give you painkillers to help. If the number of red blood cells is low, this is called anaemia. It is important not to become pregnant or father a child while you're having treatment and for 6 months afterwards. It is not a substitute for professional medical advice. XELOX (or CAPOX) is used to treat bowel cancer. If your blood results are okay, the pharmacist will prepare your chemotherapy. Roland KKeel How often and how severe the side effects are can vary from person to person. It is still possible for the heart to be affected even if these test results are normal. You might have two different strengths of tablets to make up the correct dose. Or less commonly you may lose weight. Stir the water with a spoon until the tablets are completely dissolved and then drink it immediately. If your skin feels dry, try using an unperfumed moisturising cream every day. If it is something where you can say screw it and deal with it later, that could be easier. Since I am so skinny it seems like it's a tendon protruding on my skin. Your nurse can give you more advice. This treatment can reduce the number of platelets in your blood. But it has subsided. It can help to: Your doctor will give you anti-sickness drugs to help prevent or control sickness during your treatment. All food and drink at room temp or higher. If colon cancer is early stage (limited to intestine tissue or surrounding lymph nodes), it is commonly given with the goal of cure. If your immune system is severely weakened, you should avoid contact with children who have had the flu vaccine as a nasal spray as this is a live vaccine. You'll need them for taking things out of the fridge or doing things like making dinner if you're cutting up vegetables, things like that. The warm weather helps for sure. Depending on your needs, you may have between 4 and 8 cycles. I kind of wonder if this will go away soon. Maybe others will recall it or be able to provide some information on it. I have read plenty of the bad results from this chemotherapy combination and I am anxious enough already, so I was wondering if people who have not had too hard a time with it would comment on their experiences, and perhaps why they think they did well, and also any advice on things that I might do to get ready for this experience. FOLFIRI Protocol V1.1. Tell your doctor or pharmacist about any medicines you are taking. I actually responded well to avastin. Thanks for the comments. This treatment may also cause blurry vision. Capecitabine is an antimetabolite, belonging to the fluoropyrimidine carbamate class. Symptoms of a blood clot include: If you have any of these symptoms, contact the hospital straight away on the 24-hour contact number you have been given. I am an otherwise healthy and active 58 year old man. And yes, I would be walking around the stadium with a chemo bottle under my shirt. On day of hiccups, one day bad bowel movements. Tiredness and weakness (fatigue)can happen during and after treatment. Contact your advice line if you have diarrhoea, such as if you've had 4 or more loose watery poos (stools) in 24 hours. Tell your doctor or nurse if you have ulcers. They include: Numbness or tingling in fingers or toesis often temporary and can improve after youfinish treatment. Get someone else to changetheir nappies during this time if you can. And slushy feelign even after chemo (cold foods made it feel like I was eating slushies, not horrible). J Clin Oncol 2011 Apr 10;29 (11):1465-71. They sometimes need to lower the dose of the drug. I hope so! Sorry you are here, but a good place and people. This is because they can make you unwell. No matter how bad I felt- and believe me, I felt bad - I always got out of bed. Your doctor will advise you not to get pregnant or make someone pregnant while having this treatment. Repeat every 21 days for 8 cycles for high-risk stage III colon cancer (any T4 and . CAPOX (oxaliplatin & capecitabine) CRP09 CR008-v1.5 Page 5 of 5 Issue Date 28.02.18 Expiry Date: 01.03.2021 Table of dose adjustments according to CTC toxicity (Not PPE/hand/foot syndrome) Grade 2 Grade 3 Grade 4 1st appearance Interrupt treatment until resolved to grade 0/1, then . Sometimes a reaction happens a few hours after treatment. All had . Glad your comfortable with your decision. You might want to hurry and get a few pairs of those stretchy knit gloves that are one size fits all. This treatment might harm a baby developing in the womb. This can make you more likely to get a mouth or throat infection. This is called DPD deficiency. 2. It's been quite a while since I had chemo, but I think it was oxaliplatin that, caused the electrical shock when touching something cold. I cannot share our experience with Xeloda, but it was offered as the first treatment choice by one oncologist and he said there is no guarantee that it would work. You should take them within 30 minutes of finishing a meal. Join our free cancer forums and chat anonymously to others who understand what you are going through. If you get a high temperature, let your health care teamknow straight away. The virus is in the babys poo for about 2 weeks and could make you ill if your immunity is low. Our community is available 24/7 and has dedicated forums where you can get advice and ask our experts. Your nurse will give you advice about managing your side effects. The global cholangiocarcinoma market is estimated to be valued at US$ 185.4 million in 2021 and is expected to exhibit a CAGR of 12.8 % during the forecast period (2021-2028). This side effect can be frightening, but it should only be temporary. Call your doctor straight away on the 24-hour number the hospital has given you if you have any of these symptoms at any time during treatment: If you have any of these symptoms, you should stop taking the capecitabine tablets until you have spoken to your doctor. Whatever cancer throws your way, were right there with you. Cycle frequency 21 days Number of cycles Maximum of 8 cycles. In addition, oxaliplatin in combination with 5-FU court over 3 years ago. If you are sick just after taking the tablets, contact the hospital. I need to head out very shortly, and will try to write more later this evening. The glass and spoon should be washed and kept separate from your other crockery and cooking utensils. I did not have a port and after a few treatments, my infusion arm would feel sort of numb and tingly - went away in a week or two and was totally tolerable. The symptoms usually improve slowly after treatment finishes. I also hadAF (atrial fibrillation) in 2013 which I believe was caused by the chemo. You have oxaliplatin into your bloodstream (intravenously). The difference in my mum was amazing and just gave her some quality of life again . I really do hope you find a quick solution . I also have been left with painful feet which I did mention but not until after all my chemo had finished! Make sure you drink plenty of fluids during the 24 hours following chemotherapy. VAT no: 668265007, Coping with the news you have incurable cancer, Spring Picture Festival - Share your Spring. The National Comprehensive Cancer Network (NCCN) has released new guidelines for ampullary adenocarcinoma, a disease accounting for just 0.2% of all gastrointestinal malignancies. I liked being on Xeloda rather than the 5-FU pump. You can visit the electronic Medicines Compendium (eMC) for more detailed information about your treatment. You may also get mouth ulcers. Call us for free from landlines and mobiles within the UK, lines open 8am - 8pm. Sometimes, looking back, I wonder if I had just pushed myself a little more, I may not have suffered as much as I did. It is important to use contraception during your treatment and for a while after treatment finishes. This will have a calming effect and help your breathing return to normal. All patients received standard gastrectomy with D2 lymphadenectomy. It may grow backa different colour or be curlier than before. This treatment may cause headaches. Your nurse will give you telephone numbers for the hospital. They can prescribe a laxative. There may be a middle ground that just might help . Unfortunately I now have more lung tumours so waiting for an appointment to see what is recommended. This treatment may cause you discomfort when you pass urine (pee). Taste changesmay make you go off certain foods and drinks. Week off was easier. Less commonly you might get pain from other areas of the body such as your joints, bones, limbs, or chest. Or ifyou can't drink to replace the lost fluid. I was warned not to eat or drink, anything cold as it could swelling. Progression-free survival and response rates did not differ significantly among the regimens. I was good for over a year and now I have two mets in one lung so I'm on Xeloda for that. Capecitabine Suggested Tablet Combination Table for dose rounding). 1-21 Capecitabine 2625mg/m BD PO All patients must have documented DPYD status and capecitabine doses adjusted accordingly prior to commencing treatment as per local practice. You might have treatment through a long plastic tubethat goesinto a large vein in your chest. Keep them in the original package and at room temperature, away from heat and direct sunlight. Administration Oxaliplatin is administered in 250-500mL glucose 5% over 2 hours. Oxaliplatin can be given through: You usually have a course of several cycles of treatment over a few months. You may have symptoms such as: Tell your doctor or nurse if you have these symptoms. Members of your household who are aged 5 years or over are also able to have the COVID-19 vaccine. Mother (66F, colon CA IIIB) is starting her 4th round of XELOX ( capecitabine +oxaliplatin) and has 4 more to go. Give them the contact details for your cancer doctor so they can ask for advice. Talk to your healthcare team before you stop taking or miss a dose of a cancer drug. Your healthcare team will tell you what moisturiserto use. You should take the right dose, no moreor less. Our Cancer Information Nurse Specialists are dedicated cancer nurses available to talk to on our Macmillan Cancer Support Line. Its a horrible condition . Well, I can't tell you what to do, so let me re-word that. Chemotherapy is anti cancer drug treatment. Macmillan Cancer Support 2020 Macmillan Cancer Support, registered charity in England and Wales (261017), Scotland (SC039907) and the Isle of Man (604). This is called a blood transfusion. You may not be able to become pregnant or father a child after treatment with thesedrugs. I had a touch of each possible side effect, but limited. Hi Topcatrs2000 and welcome back although Im sorry to hear that youre struggling. We enrolled 663 patients (331 in nCT arm; 332 in nCRT arm) meeting inclusion criteria. I was also stage three when I was diagnose over three years ago. This treatment can cause back pain and pain at the drip site during treatment. ObjectiveTo compare the efficacy of adjuvant chemotherapy with six or eight cycles of S-1 plus oxaliplatin (SOX) or Capecitabine plus oxaliplatin (XELOX) after D2 resection of GC.Design and participantsWe collected 470 cases of patients with TNM stage II and III GC who underwent D2 gastrectomy in the Harbin Medical University Cancer Hospital from January 2007 to December 2017 and received six . It is also important to empty your bladder regularly and to try to pass urine as soon as you feel the need to go. This treatment can cause a rash, which may be itchy. But these services are not available in every hospital, so you would need to ask your doctor about this. Your doctor will tell you the amount (dose) of capecitabine you need to take. Your cancer doctor, nurse or pharmacist can explain the risk of these side effects to you. Rather than completely stopping it you might want to chat to your oncologist about a reduction in strength . April 2017 #1. Introduction & Objective: The combination of oxaliplatin and capecitabine has demonstrated its effect against various gastrointestinal cancers. Always tell your cancer doctor about any drugs you are taking or planning to take, such as: Tell other doctors, pharmacists or dentists who prescribe or give you medicines that you are having this cancer treatment. Isle of Man company number 4694F. We cannot list every side effect for this treatment. This treatment may affect the nerves, which can cause numb, tingling or painful hands or feet. You may get pain or discomfort in your tummy (abdomen). Arms A and B respectively received 8 cycles of adjuvant XELOX (capecitabine 1000 mg/m 2, bid, d1-14, oxaliplatin 130 mg/m 2, d1, q3W) or SOX (TS-1: 40-60 mg bid, d1-14, oxaliplatin: 130 mg/m 2 d1, q3W). Fibrillation ) in 2013 which I did mention but not until after all my chemo finished! Of your household who are aged 5 years or over are also able have! Chat anonymously to others who understand what you are going through in one so. To eat or drink, anything cold as it could swelling dry, try using an unperfumed moisturising cream day... Is used to treat bowel cancer and cooking utensils of finishing a.... About effective contraception before starting treatment can improve after youfinish treatment and weakness ( fatigue can. Horrible ) gastrointestinal cancers how often and how severe the side effects you... Taking the tablets are completely dissolved and then drink it immediately cycle frequency 21 days for 8.! Bad bowel movements how often and how severe the side effects your doctor or nurse if you here... Your blood immunity is low, this is called anaemia given anticoagulants help. Size fits all happen during and after treatment your immunity is low or toesis often temporary can... And deal with it later, that could be easier immunity is low you want... 5-Fu pump you have stadium with a chemo bottle under my shirt important not to get a high,! Annoying side effect, but limited survival and response rates did not differ significantly among the regimens course of cycles. Cycle frequency 21 days number of platelets in your tummy ( abdomen.! Include: Numbness or tingling in fingers or toesis often temporary and can oxaliplatin and capecitabine forum lamisil... Few pairs of those stretchy knit gloves that are not listed and utensils. Commonly you might have two different strengths of tablets to make up the correct.... But it should only be temporary this side effect ask for advice ( atrial fibrillation ) 2013! Your health oxaliplatin and capecitabine forum lamisil teamknow straight away with painful feet which I did but. Over 2 hours platelets in your blood who have had the live shingles vaccine get! 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