Nothing. We gave our one year old Simparica tonight and he started having trimmers that lasted on and off for about 30 minutes. Gave my 12 year old labradoodle simpatico just before going to my sons for T-Day dinner. They would clear up after a round of antibiotics but would return the next month. They could either keep her there for observation or I could take her home to observe her. This neurotoxin destroys fleas, ticks, and other insects for 35 days after your dog takes the medicine. Now we are out thousands of dollars when every event has been triggered by Simparica Trio. It has been five days and the diarrhea started on day 2. Dog takes a pill highly recommended by his lifelong vet, and weeks later, after blood tests, xrays, ultrasounds, and needle aspiration, were talking euthanasia. We did not make the connection until today. 32,374 Adverse Event Reports in Dogs. Overview. Update:(12/20/21) my dog has now been able to go up and down steps with no hesitation. I feel like the simperica trio has somehow affected his Pituitary/Andrenal glands are maybe even acting as blockers to them. She's pacing and wants to eat grass. He is otherwise normal and healthy. Ours lasted about a week. well my lola went into labor xmas day. Plus I spent a fortune for the crap We gave our Pomeranian the first dose of simpatica on 4/30 - yesterday (5/11) she had a seizure and just had another one tonight. Random vomitting is no fun either. We wont be using this medicine ever again! Thirst and urination issues, Possible heart murmur this waned but there is enlargement now at the 4th month at which point Buddy went into steep decline. I do know that she was a healthy and somewhat energetic 10 year old before the treatment. It is still hard for me to get through this because I cant believe a company is getting away with killing animals and they dont care, so please , I know a lot of pet owners have no issues but do you really want to take that chance? Here is the safety info from the manufacturer Zoetis: SIMPARICA TRIO was administered orally to 8weekold Beagle puppies at doses of 1, 3, and 5X the maximum labeled dose (2.4 mg/kg sarolaner, 48 g/kg moxidectin, and 10 mg/kg pyrantel) at 28 day intervals for 7 treatments. Supposedly it is MDR1 friendly but side effects include ataxia which is what my girl got. All dogs treated with SIMPARICA TRIO were negative for D. immitis antigen and blood microfilariae at study completion on day 330. So, it is also present in Simparica TRIO. Our guy is having pain and is showing arthritic symptoms. I warned my aunt not to give this edible insecticide/arachnicide to her dog because I have heard some bad news about it, but my aunt just did not heed the warning. I am a physical therapist, and acquired Sadie to serve as a Therapy Dog in our clinic. Same here! and to only let him out on a leash to go potty. Needless, to say I will not be giving them the simparica trio again. He has been barking a lot more than he used to. No this puppy hasnt had seizures and I came to this forum to see other problems with this medicine. This was the first time she was given this drug and will be the last. So I did. My Pomeranian is on a steady decline after taking 1 dose. Coton de Tulear. gave this to my dog three different times. They both got similar issues and this was the only thing they both did. My 14 year old, 3.5 lb Chihuahua (picture the tan colored Taco Bell Chihuahua, identical) received a tablet that I cut in 4 pieces and buried in his food. I'm totally stopping the drug, but, unfortunately, can't get in to my vet for almost a month to get a replacement. 4 1/2 yr old Yorkie on May 4,2022 and on May 28,2022 she had 7 seizures in 4 1/2 hrs. Thank you all so much!!!! Instead it has become a world of greed. For the first time in 12 years my dog has 6-7 large kidney stones which will require surgery. Use topical or a collar if you are concerned. He has no appetite, wont drink water and his mouth is so dry. We took him to a different emergency vet who took us a bit more seriously and looked into his sugars and liver bile levels. Stopped meds and he has had 3 more seizures since. She definitely is not herself and behaving strangely. I bought chicken last night he ate some of that . The American Heartworm Society recommends year-round heartworm prevention for all dogs in the United States, and the Companion Animal Parasite Council recommends broad-spectrum parasite control to prevent heartworms, intestinal parasites, fleas, and ticks for all dogs in North America. The other has had diarrhea every since 6 hours after the pill. Keep the medication in the blister packs provided until ready to use in order to protect from moisture and light. He has all the symptoms Eveyone is describing. Supply ran out, switched to Simperica. lola weighs about 9lbs. We took him to vet and they gave nausea meds and kept him overnight. Will not eat or drink. I took him to the energy vet in the morning, he couldnt find any cause for pain, only he yelped a bit on his neck, they had trouble getting him in, he was yanking his neck around as he is afraid of the vet since getting fixed. I hope the best for you and dog, I know its a tough time. Every good pet parent wants to keep fleas off his dog, but many worries about the side effects that can accompany various flea and tick treatments. And now I'm upset with myself for giving this to my dog without doing research. It's definitely not! The most common adverse reactions in clinical trials were vomiting and diarrhea. I feel so sad for you Camelia. Read package insert - yes was tested on female dogs who were bred. This morning was the first morning he left water in his bowl. Poor dog prob thinks HE did something wrong. Bellas suffered an 8 month bout of puppy strangles (autoimmune disorder) starting at 11 weeks of age. Thank you for giving information on what happened to your dog. The door is open , its where he prefers to sleep on a doggie bed . I'm more concerned about fleas and heartworms and Trifexis is just fine for that. This is not at all his behavior. Vets at Petsmart should know better; changing vets. Im worried sick. She has been on it for 6 months. Omg my girl goes threw incredible itching this has lead to us takeing her to the vet because she gets infected from scratching herself to death. They then told us to follow up with a neurologist if it happened again. 24 hours later she had another one. I gave my six-year-old dog SIM perica because the combo guard was on back order. The neurologist suggested we start by stopping the Simparica and using a flea and tick with no seizure side effects. She seems more anxious now and really attached to hubby. Our dog has had 2 Seizures this month and we are going to stop using Simparica. Simparica has been approved by the FDA to treat and prevent flea and tick infestations. Seizures continue and its Monday. i know this med did this to her , she was on for a year and half , i should never ever have listened to the vet and went with my gut, but again they assured me since she was healthy be very rare she would have side effects smdh and plus been in contract with the makers of this horrible medication they all should be ashamed of themselves!!!!!!!!!!! I gave my 2 yr old, very healthy, German short hair her first dose on Friday night and by Saturday morning she was vomiting about every 2 hours. She was being seen by her regular vet and was put on antibiotics. Three-month field trials found side effects from Simparica to be rare, with the most common adverse reactions being vomiting and diarrheaboth symptoms related to Fido's digestive tract, rather than his nervous system. Gave my dog Charlie Simparica yesterday now he is shaking and panting really bad. like she wants me to fix it. She continued to have seizures even she was on phenobarbital. Now it is March, on Tuesday I gave him his de-wormer and Wednesday he had a seizure. It's unique because it kills more types of parasites than any other combination product available to date. It is better but not gone. In about 3-4 days he threw up clear liquid, then went into spells where he coughed so hard it sounded like he was barking and screaming at the same time. This is happening now and she is still nowhere near 100% but I am hopeful that she will eventually fully recover. They did an ultrasound (2 of them), X-rays, blood test, gave fluids, did another ultrasound (looking for a master fluid that keeps popping up and going away between her stomach cavity & spinal cord. Simparica trio is a de-worming medication. If you give your dog or cat the flea and tick preventatives Bravecto, Nexgard, Simparica, or Credelio, the FDA wants you to be aware that these medications may cause neurological issues like stumbling, seizures, and twitching in your pet.Though these products are FDA-approved, data received by the agency as part of its post-marketing activities showed the potential for adverse neurological . I gave this poison to my almost 3 year old Yorkie she is dying as I right this. around 12 years She grabs and won't let go. Saving money sounds great, right? They may not be ready to beat you in a game of chess, but these brainy dogs are easy to train and generally eager to please you. My son's girlfriends 2 year old pit bull mix rescue dog just had to be euthanized after a week long battle with the side effects of a flea/tick med.The girl had given her dog the one dose and immediately after ,the dog started having shaking and weakness in the back legs.Took her to an emergency vet.Was given fluids and had blood tests to see if there were poisons such as xylitol or nicotine in her sytem.No problems.$900 later..jsu 2-3 hours on fluids she was released with no answers.The vet wanted him(as his girlfriend was out of town for the holiday at this point) to bring the dog back on Xmas day to check her blood again.He figured another huge charge so was going to try to wit until after the holiday to see a regular vet who charges normal rates and that vet didn't do a thing for $900.00.The dog got progressively worse.Couldn't walk ,couldn't eat ,couldn't bark.Eyes were darting from side to side.Come Monday morning and no regular vet office would see her as they said she needs to go to another vet hospital.They wanted 2,600.00 from my son right up front for an overnight stay.They said she was having seizures but she would get better they thought so he left her.The next morning they said she needed more days in the hospital.My son said they as they don't make a ton of money could not afford this and we had to wait until his girlfriend got home the next day.He wanted to take the dog home.They said they would keep the dog for free for 12 hours..Meanwhile I called the manufacturer to open a case and they spoke to the vet and authorized some funds to help with what the Vet said was "future costs".That afternoon ,a different vet called and said the dog was having cluster seizures and she didn't think it was going to make it and that it should be put down so my Son and his girlfriend made the terrible decision to do that.My son was with the dog and her owner face timed to speak to her pet as she was being euthanizeda terrible tramatizing ordeal.Next thing you know,my son gets the ivoice from the Vet and it is over 5,000.00. Simparica Trio is safe to give in conjunction with most other medications, but be sure to tell your vet about all medications and supplements you give to your dog. I have a vet appointment tomorrow to figure it out. OMG - I am so mad at myself for not doing more research. I argued with the vet that this is poison and she said why would I give your dog poison? They still will not consider that it is the Simparica Trio. Simparica chewable is a preventative that is better suited to healthy adult dogs living in areas where ticks are prevalent. Does this sound familiar to anyone? What kind of supplements are you giving her? I researched simparica after she started exhibiting problems and I have little doubt that this is what caused her problems. I suppose with any drug, during trials, there will be some who have side effects ranging from negligible to life threatening. Tested on female dogs who were bred last night he ate some of that morning the! 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